Feb 25, 2002 · These constructs optimize a novel fold, designated as the 'Trp-cage' motif, and are significantly more stable than any other miniprotein reported to date. Folding is cooperative …

Jun 18, 2021 · The tryptophan-cage or "Trp-cage" is thought to be the smallest protein-like folding motif. The Trp-cage mini proteins are small, folded peptides with 18 to 20 residues in length.

The original Trp-cage (NLYIQWLKDGGPSSGRPPPS, Tm = 42 degrees C) can be significantly stabilized by mutations; melting points as high as 64 degrees C are reported.

Sep 4, 2013 · Trp-cage is a synthetic 20-residue miniprotein which folds rapidly and spontaneously to a well-defined globular structure more typical of larger proteins. Due to its …

Mar 9, 2007 · The original Trp-cage (NLYIQWLKDGGPSSGRPPPS, Tm = 42 degrees C) can be significantly stabilized by mutations; melting points as high as 64 degrees C are reported.

Nov 11, 2023 · Proteins that do not fold into their functional native state have been linked to diseases. In this study, the influence of the main and side chains of individual amino acids on …

Using action-derived molecular dynamics (ADMD), we study the dynamic folding pathway models of the Trp-cage protein by providing its sequential conformational changes from its initial …

设计具有20个残基的小蛋白Trp-cage（色氨酸笼），由于它非常小并且很容易折叠，使它成为架起理论和实验桥梁的理想的模型。

Sep 10, 2024 · We highlight the indirect role of Ex4's structure-stabilizing Trp-cage (Tc) motif in governing GLP-1 receptor (GLP-1R) signal transduction. We use various Ex4 derivatives to …

Jan 18, 2008 · The original Trp-cage (NLYIQWLKDGGPSSGRPPPS, Tm = 42°C) can be significantly stabilized by mutations; melting points as high as 64°C are reported. In helical …